新加坡鄧懿禎、戴偉君兩位博士來我校做學術報告

報告題目：The Role of Autophagy in Fungal Development and Pathogenesis

報告人：鄧懿禎 博士

報告題目：Post-transcriptional Autoregulation of mHuR Expression

報告人：戴偉君 博士

報告時間：5月24日上午9:00

報告地點：六號樓學術報告廳

歡迎廣大師生參加！

人事處

生命科學學院

2012年5月22日

鄧懿禎 博士 簡介

Contact

Deng Yizhen 鄧懿禎

Address: (Home) Singapore Blk602,#06-26, Clementi West Street 1, Singapore, S120602

               (Working) Fungal Patho-biology Group, Temasek Life sciences Laboratory, 1 Research Link, National University of Singapore 117604

E-mail: yizhen@tll.org.sg

Mobile: 65-90411082

Education  

1999-2003     B. Sc, School of Lifesciences, Sun-Yat sen University, Guangzhou, PRC

2005-2011     Ph. D, National University of Singapore

Working experiences  

2004.9-2011.2    Temasek Lifesciences Laboratory, Junior Research Fellow

2011.2-now (current contract ends by Feb 2013)      Temasek Lifesciences Laboratory  Research Fellow (post-doctoral)

Awards

2007.8-2010.8 Singapore Millenium Foundation Scholarship for Ph.D student

International conferences attending 

2007.10 The 4th IRBC (International Rice Blast Conference), Changsha, China

2008.6 Gordon research conference on The Cellular and Molecular Fungal Biology

2009.8 EMBO meeting, Amsterdam, NL

2009.11 International meeting on Peroxisome research, Seattle, US

2010.4 Gordon research conference on Autophagy in Stress, Development and Disease, Luca, Italy

Publication

Deng YZ, Qu ZW, He YL, Naqvi NI. (2012) Sorting Nexin Snx41 is essential for conidiation and mediates glutathione-based antioxidant defense during invasive growth in Magnaporthe oryzae. Autophagy 8(7) (In press)

Deng, YZ and NI Naqvi. 2010. A vacuolar glucoamylase, Sga1, participates in glycogen autophagy for proper asexual differentiation in Magnaporthe oryzae. Autophagy 6: 455-461.

Deng, YZ, M Ramos-Pamplona and NI Naqvi. 2009. Autophagy-assisted glycogen catabolism regulates asexual differentiation in Magnaporthe oryzae. Autophagy 5: 33-43. Cover feature.

Deng, YZ, M Ramos-Pamplona and NI Naqvi. 2008. Methods for the functional analysis of macroautophagy in filamentous fungi. Methods in Enzymology. 451: 295-310.

Sun, CB, A Suresh, YZ Deng and NI Naqvi. 2006. A Multidrug Resistance Transporter in Magnaporthe is Required for Host Penetration and for Survival during Oxidative Stress. The Plant Cell. 18: 3686-3705.

Manuscript in preparation:

Deng, YZ and Naweed I. Naqvi. Role of Macroautophagy in Nutrient Homeostasis during Fungal Development and Pathogenesis. (Review for The Cells)

Deng, YZ and Naweed I. Naqvi. Functional Study of the Role of Pexophagy in Magnaporthe oryzae Asexual Development and Pathogenesis. (Report. intend to submit to PLoSONE)

Referee

Prof. Naweed NAQVI

Tel: (65) 6872 7000, 6872 7493 (DID) or 6872 7087 (lab)

Email: naweed@tll.org.sg

Prof. Snezhaka OLIFERENKO

Tel: (65) 6872 7000, 6872 7490 (DID) or 6872 7494 (lab)

Email: snejana@tll.org.sg

戴偉君 博士 簡介

Contact

Dai Weijun 戴偉君

Address: Division of Molecular & Cell Biology,School of Biological Sciences, Nanyang Technology University, SBS-02n-41, 60 Nanyang Anenue, Singapore 637551

Tel. 65-81966859 (mobile)

Email: daiweijun@gmail.com

            wjdai@ntu.edu.sg

Education  

1997-2001    B. Sc, Sun-Yat sen (ZhongShan) University, Guangzhou, PRC

2001-2004     M.Sc., Sun-Yat sen (ZhongShan) University, Guangzhou, PRC

2005-2008     Ph.D., Sun-Yat sen (ZhongShan) University, Guangzhou, PRC

Woking Experiences

2008 July-present  Postdoctoral Fellow

School of Biological Sciences, Nanyang Technological University, Singapore 

Research interests  (stem cell / neuron differentiation /microRNA/cancer)

My research interest lies in understanding the significance of post-transcriptional RNA-based processes for stem cell differentiation (particularly in neuron differentiation), microRNA regulation and cancer development. Gene expression in eukaryotes is subject to extensive regulation at posttranscriptional levels. One of the most important sites of control involves mRNA 3′ untranslated regions (3’UTR), which are recognized by RNA-binding proteins (RBPs) and microRNAs. These factors greatly influence translational efficiency and stability of target mRNAs and often also determine their cellular localization. HuR, a ubiquitously expressed member of RBPs, has been implicated in regulation of stability and translation of over one hundred mRNAs in mammalian cells. HuR involves control of apoptosis, hormone responses, stress tolerance, differentiation, metabolism and development etc.

Ph.D. research topic

Establishment of symbiosis between certain host plants and nitrogen-fixing bacteria depends on type 3 secretion system (T3SS) effectors. NopT is a novel T3SS effector of Rhizobium sp. strain NGR234. NopT possesses autoproteolytic activity. This functional protease activity leads to symbiosis-promoting on Phaseolus vulgaris cv. Yudou No. 1; Tephrosia vogelii while deleterious effects upon Crotalaria juncea.

PUBLICATIONS

Dai WJ, Zhang G, Makeyev EV. RNA-binding protein HuR autoregulates its expression by promoting alternative polyadenylation site usage. Nucleic Acids Res. 2011 Sep 24. Featured Articles

Dai WJ, Zeng Y, Xie ZP, Staehelin C. Symbiosis-promoting and deleterious effects of NopT, a novel type 3 effector of Rhizobium sp. strain NGR234.J Bacteriol. 2008 Jul;190(14):5101-10. Epub 2008 May 16.

Yang FJ, Cheng LL, Zhang L, Dai WJ, Liu Z, Yao N, Xie ZP, Staehelin C. Y4lO of Rhizobium sp. strain NGR234 is a symbiotic determinant required for symbiosome differentiation.J Bacteriol. 2009 Feb;191(3):735-46. Epub 2008 Dec 5.

Referee

Prof. Eugene Makeyev

School of Biological Sciences

Nanyang Technological University

60 Nanyang Drive, SBS-02n-45

Singapore 637551

Phone (work): +65-6513 8151

Email: makeyev@ntu.edu.sg

Prof. Christian Staehelin

State Key Laboratory of Biocontrol

School of Life Sciences

Sun Yat-sen (Zhongshan) University, East Campus

Guangzhou, 510006, China

Email: cst@mail.sysu.edu.cn