報(bào)告題目是：Coordinated transcriptional regulation underlying the
circadian clock in Arabidopsis
內(nèi)容摘要：
The circadian clock controls many metabolic, developmental and physiological processes in a time-of-day-specific manner in both plants and animals1. The
photoreceptors involved in the perception of light and entrainment of the
circadian clock have been well characterized in plants. However, how light
signals are transduced from the photoreceptors to the central circadian
oscillator, and how the rhythmic expression pattern of a clock gene is
generated and maintained by diurnal light signals remain unclear. Here, we
show that in Arabidopsis thaliana, FHY3, FAR1 and HY5, three positive
regulators of the phytochrome A signalling pathway, directly bind to the
promoter of ELF4, a proposed component of the central oscillator, and
activate its expression during the day, whereas the circadian-controlled
CCA1 and LHY proteins directly suppress ELF4 expression periodically at dawn
through physical interactions with these transcription-promoting factors.
Our findings provide evidence that a set of light- and circadian-regulated
transcription factors act directly and coordinately at the ELF4 promoter to
regulate its cyclic expression, and establish a potential molecular link
connecting the environmental light–dark cycle to the central oscillator.
報(bào)告人：李剛（Postdoctoral associate，The Department of Molecular, Cellular and Developmental Biology, Yale University）
時(shí)間：2011年5月20日下午3：00
地點(diǎn)：6號(hào)樓學(xué)術(shù)報(bào)告廳
生命科學(xué)院 人事處
circadian clock in Arabidopsis
內(nèi)容摘要：
The circadian clock controls many metabolic, developmental and physiological processes in a time-of-day-specific manner in both plants and animals1. The
photoreceptors involved in the perception of light and entrainment of the
circadian clock have been well characterized in plants. However, how light
signals are transduced from the photoreceptors to the central circadian
oscillator, and how the rhythmic expression pattern of a clock gene is
generated and maintained by diurnal light signals remain unclear. Here, we
show that in Arabidopsis thaliana, FHY3, FAR1 and HY5, three positive
regulators of the phytochrome A signalling pathway, directly bind to the
promoter of ELF4, a proposed component of the central oscillator, and
activate its expression during the day, whereas the circadian-controlled
CCA1 and LHY proteins directly suppress ELF4 expression periodically at dawn
through physical interactions with these transcription-promoting factors.
Our findings provide evidence that a set of light- and circadian-regulated
transcription factors act directly and coordinately at the ELF4 promoter to
regulate its cyclic expression, and establish a potential molecular link
connecting the environmental light–dark cycle to the central oscillator.
報(bào)告人：李剛（Postdoctoral associate，The Department of Molecular, Cellular and Developmental Biology, Yale University）
時(shí)間：2011年5月20日下午3：00
地點(diǎn)：6號(hào)樓學(xué)術(shù)報(bào)告廳
生命科學(xué)院 人事處
責(zé)任編輯：kyc
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